|
Uterine Fibroids
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits.
|
30194396 |
2018 |
|
Uterine Fibroids
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis.
|
31649266 |
2019 |
|
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
The results above indicate that upregulating the Kank1 gene can inhibit the progress of gastric cancer in vivo and in vitro and its mechanism is closely relevant to apoptosis and the tumor invasion and metastasis.
|
28731169 |
2017 |
|
Tumor Cell Invasion
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
In the METABRIC cohort, high expression of KANK1 mRNA was associated with characteristics of good prognosis including lower grade, absence of lymphovascular invasion and HER2 negativity (all; p < 0.001) and with better outcome [p = 0.006, Hazards ratio, (HR) 0.70, 95% CI 0.54-0.91].
|
31679074 |
2020 |
|
Thrombocytosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
KANK1-PDGFRB is a unique example of a thrombocythemia-associated oncogene that does not signal via JAK2.
|
21685469 |
2011 |
|
Stomach Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The results above indicate that upregulating the Kank1 gene can inhibit the progress of gastric cancer in vivo and in vitro and its mechanism is closely relevant to apoptosis and the tumor invasion and metastasis.
|
28731169 |
2017 |
|
Spastic Quadriplegia
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Renal Cell Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Kank1, which was first described as a potential tumor suppressor for renal cell carcinoma (RCC), mapped to 9p24.3 and encoded an ankyrin-repeat domain-containing protein.
|
25973051 |
2015 |
|
Renal Cell Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
The Kank gene was found as a candidate tumor suppressor gene at 9p24 by loss-of-heterozygosity search in renal cell carcinoma (RCC) and seems to have a role in controlling the formation of the cytoskeleton through the polymerization of actin.
|
15596059 |
2005 |
|
Renal carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
It was recently discovered that the Kank1 gene is a new cancer suppressor, and its expression is significantly downregulated or it is not expressed in kidney cancer, bladder cancer, prostate cancer, lung cancer and breast cancer.
|
24399197 |
2014 |
|
Primary malignant neoplasm of lung
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
It was recently discovered that the Kank1 gene is a new cancer suppressor, and its expression is significantly downregulated or it is not expressed in kidney cancer, bladder cancer, prostate cancer, lung cancer and breast cancer.
|
24399197 |
2014 |
|
Primary malignant neoplasm of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
However, there is no study concerning the specific role of Kank1 in the development and progression of lung cancer.
|
29956815 |
2018 |
|
Primary malignant neoplasm
|
0.010 |
AlteredExpression
|
group |
BEFREE |
It was recently discovered that the Kank1 gene is a new cancer suppressor, and its expression is significantly downregulated or it is not expressed in kidney cancer, bladder cancer, prostate cancer, lung cancer and breast cancer.
|
24399197 |
2014 |
|
Polycythemia Vera
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Patients with PV who were homozygous or heterozygous for JAK2-V617F exhibited higher levels of expression of the 13 new markers, PRV1, and NF-E2 than patients without JAK2-V617F, whereas ANKRD15 was down-regulated in these patients.
|
16081684 |
2005 |
|
Plexiform leiomyoma
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis.
|
31649266 |
2019 |
|
Plexiform leiomyoma
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits.
|
30194396 |
2018 |
|
Nicotine Dependence
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, rs2241617 in ZCCHC14 and rs4742225 in KANK1 showed strong associations with ND (p=1.06×10(-7) and 4.81×10(-7), respectively) in the replication sample.
|
22377092 |
2012 |
|
neurofibroma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Consistently, knockdown of KANK1 in neurofibroma cells promoted cell growth.
|
28067315 |
2017 |
|
Neurodevelopmental Disorders
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Clinical significance of copy number variants involving KANK1 in patients with neurodevelopmental disorders.
|
29729439 |
2019 |
|
nervous system disorder
|
0.010 |
GeneticVariation
|
group |
BEFREE |
We recommend searching for an alternate explanation for disease in individuals with a neurological disorder found to have a small deletion involving KANK1.
|
30684669 |
2020 |
|
Nephrotic Syndrome
|
0.320 |
Biomarker
|
group |
GENOMICS_ENGLAND |
Here, using homozygosity mapping and whole-exome sequencing, we identified recessive mutations in kidney ankyrin repeat-containing protein 1 (KANK1), KANK2, and KANK4 in individuals with nephrotic syndrome.
|
25961457 |
2015 |
|
Nephrotic Syndrome
|
0.320 |
GeneticVariation
|
group |
BEFREE |
Mutations in KANK proteins are implicated in cancers and genetic diseases, such as nephrotic syndrome.
|
29217769 |
2018 |
|
Nephrotic Syndrome
|
0.320 |
GeneticVariation
|
group |
BEFREE |
Here, using homozygosity mapping and whole-exome sequencing, we identified recessive mutations in kidney ankyrin repeat-containing protein 1 (KANK1), KANK2, and KANK4 in individuals with nephrotic syndrome.
|
25961457 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We used RNA interference techniques to silence Kank1 gene expression and found acceleration of tumor cell proliferation.
|
24399197 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We observed deletion of chromosomal segments on chr9p and chr13q, including tumor suppressor genes such as KANK1 and CDKN2A, but no gene fusions were found.
|
29141020 |
2017 |